Sodium starch glycolate
Specifications
Sodium starch glycolate is widely used in oral pharmaceuticals as a disintegrant in capsule & tablet formulations.
1. Description
Sodium starch glycolate is a white or almost white free-flowing very hygroscopic powder. The PhEur 6.0 states that when examined under a microscope it is seen to consist of: granules, irregularly shaped, ovoid or pear-shaped, 30–100 mm in size, or rounded, 10–35 mm in size; compound granules consisting of 2–4 components occur occasionally; the granules have an eccentric hilum and clearly visible concentric striations. Between crossed nicol prisms, the granules show a distinct black cross intersecting at the hilum; small crystals are visible at the surface of the granules. The granules show considerable swelling in contact with water.
2. Applications in Pharmaceutical Formulation or Technology
Sodium starch glycolate is widely used in oral pharmaceuticals as a
disintegrant in capsule and tablet formulations.
It is commonly used in tablets prepared by either direct-compres-
sion or wet-granulation processes. The usual concentration employed in a formulation is between 2%and 8%, with the
optimum concentration about 4%, although in many cases 2% is sufficient. Disintegration occurs by rapid uptake of water followed by rapid and enormous swelling.
Although the effectiveness of many disintegrants is affected by
the presence of hydrophobic excipients such as lubricants, the
disintegrant efficiency of sodium starch glycolate is unimpaired.
Increasing the tablet compression pressure also appears to have no
effect on disintegration time.
Sodium starch glycolate has al
Package
It's packed in fiber barrel and lining with polyethylene film bag Net weight 25KG per barrel.